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Nasal irrigation for chronic sinus symptoms in patients with allergic rhinitis, asthma, and nasal polyposis: a hypothesis generating study.
对因过敏性鼻炎、哮喘和鼻息肉引起的慢性鼻窦症状进行鼻腔冲洗的假说形成研究

Rabago D, Guerard E, Bukstein D.
Department of Family Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA. david.rabago@fammed.wisc.edu
美国威斯康星大学医疗与公共健康学院家庭医疗系
BACKGROUND: Rhinosinusitis is a common, expensive disorder with a significant impact on patients' quality of life. Chronic sinus symptoms are associated with allergic rhinitis, asthma, and nasal polyposis.
背景:鼻窦炎是一种常见的,高费用疾病,严重影响患者的生活质量。慢性鼻窦炎症状与过敏性鼻炎、哮喘及鼻息肉有关。
Saline nasal irrigation is an adjunctive therapy for rhinosinusitis and sinus symptoms. Prior studies suggest that saline nasal irrigation may be effective for symptoms associated with allergy rhinitis, asthma, and nasal polyposis.
盐水冲洗鼻腔是治疗鼻窦炎和缓解鼻窦症状的一种辅助手段。前期的研究显示盐水冲洗鼻腔对改善过敏性鼻炎、哮喘及鼻息肉等引起的症状有一定的作用。

OBJECTIVE: To assess the degree to which subjects using nasal irrigation for chronic sinus symptoms also reported improvements in symptoms related to allergy, asthma, or nasal polyposis.
目的:既评估鼻腔冲洗对慢性鼻窦症状的作用效果,也记录(或提供)过敏性鼻炎、哮喘和鼻息肉等相关症状的改善情况
DESIGN: Qualitative study using in-depth long interviews of 28 participants in a prior qualitative nasal irrigation study. All participants were receiving daily nasal irrigation.
设计:对28名前期参与鼻腔冲洗定性研究的患者进行深度随访定性研究。所有的参与者每天接受鼻腔冲洗。
RESULTS: Transcripts of interviews were systematically examined. Twelve of 21 subjects with allergic rhinitis spontaneously reported that saline nasal irrigation improved symptoms. Two of 7 subjects with asthma and 1 of 2 subjects with nasal polyposis reported a positive association between saline nasal irrigation use and asthma or nasal polyposis symptoms. Transcript content was organized into themes that included: (1) Saline nasal irrigation resulted in improvement of allergic rhinitis and asthma symptoms, and (2) Saline nasal irrigation should be used for symptoms of allergic rhinitis.
结果:随访记录经系统整理。21位过敏性鼻炎患者中有12位报告盐水洗鼻明显改善了症状。7位哮喘患者中的2位和2位鼻息肉患者中的1位提供的数据显示盐水洗鼻对改善相关症状的积极作用。随访记录内容被组织归纳后的结论包括:(1)盐水洗鼻可改善过敏性鼻炎和哮喘症状;(2)盐水洗鼻可用于治疗过敏性鼻炎。

CONCLUSIONS: This hypothesis-generating study offers qualitative evidence that suggests patients with frequent rhinosinusitis and daily sinus symptoms, symptoms of concomitant allergic rhinitis, asthma, or polyposis may improve with saline nasal irrigation. The parent studies offer strong evidence that saline nasal irrigation is an effective adjunctive treatment for symptoms of chronic rhinosinusitis. Larger prospective studies are needed in patients with these diagnoses.
结论:这个假说形成研究提供了定性依据,即经常罹患鼻窦炎和出现鼻窦症状的患者,以及出现过敏性鼻炎、哮喘和鼻息肉伴随症状的患者用盐水洗鼻可以改善症状。亲本研究提供有力依据显示盐水洗鼻是一种有效的慢性鼻窦炎的辅助治疗手段。有必要在这类疾病患者中进行大样本的前瞻性研究。